Engineered avian R2 retrotransposons enable targeted DNA integration in human cells
Researchers searched 1,139 avian genomes and identified 159 avian R2 retrotransposons, finding conserved and nonconserved features in their proteins and untranslated region elements. Engineered variants achieved up to 60% site-specific gene integration across human primary cells. The sequencing data were submitted to the Genome Sequence Archive for Human, a platform under the Beijing Institute of Genomics, Chinese Academy of Sciences. The accession number is HRA013312.
The findings add tools for all-RNA-mediated genome editing and targeted DNA integration in human cells.
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